2024
原著論文
Suzuki H, Sugano SS, Muranaka T, Seki H (2024). Ectopic expression of BpbHLH9 suggested the presence of a selfactivating loop mechanism of clade Ia bHLHs to enhance betulinic acid biosynthesis in Lotus japonicus hairy roots. Plant Biotechnol 41(3): 319-323. DOI: 10.5511/plantbiotechnology.24.0717b
Romsuk J, Srisawat P, Robertlee J, Yasumoto S, Miura K, Muranaka T, Seki H (2024). Heterologous production of corosolic acid, a phyto-insulin, in agroinfiltrated Nicotiana benthamiana leaves. Plant Biotechnol 41(3): 277-288. DOI: 10.5511/plantbiotechnology.24.0420a
Chiyo N, Seki H, Kanamoto T, Ueda H, Kojoma M, Muranaka T (2024). Glycyrrhizin production in licorice hairy roots based on metabolic redirection of triterpenoid biosynthetic pathway by genome editing. Plant Cell Physiol 65(2): 185-198. DOI: 10.1093/pcp/pcad161
Sakanishi M, Chung SY, Fujiwara K, Kojoma M, Muranaka T, Seki H (2024). Disruption of a licorice cellulose synthase-derived glycosyltransferase gene demonstrates its in planta role in soyasaponin biosynthesis. Plant Cell Rep 43: 15. DOI: 10.1007/s00299-023-03095-6
解説・総説、著書
Mitsuda N, Seki H, Shoji T, Hirai MY (2024). Preface to the special issue “Synthetic biology and bioproduction in plants”. Plant Biotechnol 41(3): 169-171. DOI: 10.5511/plantbiotechnology.24.0000p
Fujiyama K, Muranaka T, Okazawa A, Seki H, Taguchi G, Yasumoto S (2024). Recent advances in plant-based bioproduction. J Biosci Bioeng 138(1): 1-12. DOI: 10.1016/j.jbiosc.2024.01.007
2023
原著論文
Istiandari P, Yasumoto S, Seki H, Fukushima EO, Muranaka T (2023). Classes I and II NADPH-cytochrome P450 reductases exhibit different roles in triterpenoid biosynthesis in Lotus japonicus. Front Plant Sci 14: 1214602. DOI: 10.3389/fpls.2023.1214602
Takahashi H, Abo C, Suzuki H, Romusuk J, Oi T, Yanagawa A, Gorai T, Tomisaki Y, Jitsui M, Shimamura S, Mori H, Kaga A, Ishimoto M, Seki H, Muranaka T, Nakazono M (2023). Triterpenoids in aerenchymatous phellem contribute to internal root aeration and waterlogging adaptability in soybeans. New Phytologist 239: 936-948. DOI: 10.1111/nph.18975
プレスリリース
解説・総説、著書
關 光 (2023).「植物バイオ」の温故知新：植物組織培養、バイオサイエンスとインダストリー Vol. 81(6): 531.
關 光、Soo Yeon CHUNG、村中俊哉 (2023). サポニン生合成に関わる新しい糖転移酵素ファミリーの発見、化学と生物 Vol. 61(10): 477-483. DOI: 10.1271/kagakutoseibutsu.61.477
2022
原著論文
Rai A, Hirakawa H, Rai M, Shimizu Y, Shirasawa K, Kikuchi S, Seki H, Yamazaki M, Toyoda A, Isobe S, Muranaka T, Saito K (2022). Chromosome-scale genome assembly of Glycyrrhiza uralensis revealed metabolic gene cluster centred specialized metabolites biosynthesis. DNA Res 29: 1-14.
DOI: 10.1093/dnares/dsac043
プレスリリース
Romsuk J, Yasumoto S, Seki H, Fukushima EO, Muranaka T (2022). Identification of key amino acid residues toward improving the catalytic activity and substrate specificity of plant-derived cytochrome P450 monooxygenases CYP716A subfamily enzyme for triterpenoid production in Saccharomyces cerevisiae. Front Bioeng Biotechnol 10:955650. DOI: 10.3389/fbioe.2022.955650
Romsuk J, Yasumoto S, Fukushima EO, Miura K, Muranaka T, Seki H (2022). High-yield bioactive triterpenoid production by heterologous expression in Nicotiana benthamiana using the Tsukuba system. Front Plant Sci 13: 991909. DOI: 10.3389/fpls.2022.991909
解説・総説、著書
關 光、Soo Yeon CHUNG、村中俊哉 (2022). 植物トリテルペノイドの酵母生産: 実例および展望、植物の生長調節Vol. 57(2): 77-83.
Soo Yeon CHUNG、關 光、村中俊哉 (2022). 酵母を用いたグリチルリチンの生産とメタボロン形成の可能性、酵素工学ニュース 第88号.
2021
原著論文
Istiandari P, Yasumoto S, Srisawat P, Tamura K, Chikugo A, Suzuki H, Seki H, Fukushima EO, Muranaka T (2021). Comparative analysis of NADPH-Cytochrome P450 reductases from legumes for heterologous production of triterpenoids in transgenic Saccharomyces cerevisiae. Front Plant Sci 12: 762546. DOI: 10.3389/fpls.2021.762546
Kawasaki A, Chikugo A, Tamura K, Seki H, Muranaka T (2021). Characterization of UDP-glucose dehydrogenase isoforms in the medicinal legume Glycyrrhiza uralensis. Plant Biotechnol 38(2): 205-218. DOI: 10.5511/plantbiotechnology.21.0222a
Fanani MZ*, Sawai S*, Seki H, Ishimori M, Ohyama K, Fukushima EO, Sudo H, Saito K, Muranaka T (*equal contribution) (2021). Allylic hydroxylation activity is a source of saponin chemodiversity in the genus Glycyrrhiza. Plant Cell Physiol 62(2): 262-271. DOI: 10.1093/pcp/pcaa173 (Selected as the Editor-in-Chief's choice paper)
プレスリリース
Suzuki H, Seki H, Muranaka T (2021). Insights into the diversification of subclade IVa bHLH transcription factors in Fabaceae. BMC Plant Biol 21:109. DOI: 10.1186/s12870-021-02887-w
解説・総説、著書
關 光、Chung Soo Yeong、村中俊哉 (2021). グリチルリチン生合成機構の解明と組換え酵母での生産、ファルマシアVol. 57(8): 710-714. DOI: 10.14894/faruawpsj.57.8_710
村中俊哉、關 光 (2021). 最新のトピックス「植物の有用成分を酵母でつくるー有機合成が難しい天然物をいかにして持続的に生産するか」、化学 Vol. 76(6): 553-555.
關 光、鈴木隼人 (2021). 続よもやま話「植物イソプレノイド生合成研究と生物工学」、生物工学会誌 Vol. 99(5): 246-249. DOI: 10.34565/seibutsukogaku.99.5_246
Chung Soo Yeong、關 光、村中俊哉 (2021). 解説「酵母を用いた植物由来の甘味成分グリチルリチンの生産」、バイオサイエンスとインダストリー Vol. 79(3): 205-209.
2020
原著論文
Chung SY*, Seki H*, Fujisawa Y, Shimoda Y, Hiraga S, Nomura Y, Saito K, Ishimoto M, Muranaka T (*equal contribution) (2020). A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis. Nat Commun 11: 5664. DOI: 10.1038/s41467-020-19399-0
メディア報道 (2020-11-20、朝日新聞デジタル、他)
プレスリリース
Srisawat P, Yasumoto S, Fukushima EO, Robertlee J, Seki H, Muranaka T (2020). Production of the bioactive plant-derived triterpenoid morolic acid in engineered Saccharomyces cerevisiae. Biotechnol Bioeng 117: 2198-2208. DOI: 10.1002/bit.27357 (Selected as the Editor's choice article)
解説・総説、著書
關 光、北村実紗子、世戸口貴宏、鈴木隼人 (2020). 大豆のサポニン含量を制御する転写制御因子の探索、大豆たん白質研究 Vol. 23: 46-51.
2019
原著論文
Fanani MZ, Fukushima EO, Sawai S, Tang J, Ishimori M, Sudo H, Ohyama K, Seki H, Saito K, Muranaka T (2019). Molecular basis of C-30 product regioselectivity of legume oxidasesinvolved in high-value triterpenoid biosynthesis. Front Plant Sci 10: 1520. DOI: 10.3389/fpls.2019.01520
Munakata R, Takemura T, Tatsumi K, Moriyoshi E, Yanagihara K, Sugiyama A, Suzuki H, Seki H, Muranaka T, Kawano N, Yoshimatsu K, Kawahara N, Grosjean J, Bourgaud F, Hehn A, Yazaki K (2019). Isolation of Artemisia capillaris membrane-bound di-prenyltransferase for phenylpropanoids and redesign of artepillin C in yeast. Communications Biol 2: 384. DOI: 10.1038/s42003-019-0630-0
Suzuki H, Fukushima EO, Shimizu Y, Seki H, Fujisawa Y, Ishimoto M, Osakabe K, Osakabe Y, Muranaka T (2019). Lotus japonicus triterpenoid profile and characterization of CYP716A51 and LjCYP93E1 genes involved in its biosynthesis in planta. Plant Cell Physiol 60(11): 2496-2509. DOI: 10.1093/pcp/pcz145
Nomura Y*, Seki H*, Suzuki T, Ohyama K, Mizutani M, Kaku T, Tamura K, Ono E, Horikawa M, Sudo H, Hayashi H, Saito K, Muranaka T (*equal contribution) (2019). Functional specialization of UDP-glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin. Plant J 99(6): 1127-1143. DOI: 10.1111/tpj.14409
Srisawat P, Fukushima EO, Yasumoto S, Robertlee J, Suzuki H, Seki H, Muranaka T (2019). Identification of oxidosqualene cyclases from the medicinal legume tree Bauhinia forficata: a step toward discovering preponderant α-amyrin-producing activity. New Phytol 224(1): 352-366. DOI: 10.1111/nph.16013
Muangphrom P, Misaki M, Suzuki M, Shimomura M, Suzuki H, Seki H, Muranaka T (2019). Identification and characterization of (+)-α-bisabolol and 7-epi-silphiperfol-5-ene synthases from Artemisia abrotanum. Phytochemistry 164: 144-153. DOI: 10.1016/j.phytochem.2019.05.010
解説・総説、著書
關 光、高上馬希重、村中俊哉 (2019). グリチルリチン酸生合成制御の理解に向けて、アグリバイオVol. 3(11): 1038-1041.
2018
原著論文
Nakamura M, Tran ML, Le QL, Suzuki H, Nguyen CM, Vu HG, Tamura K, Nguyen VT, Suzuki H, Misaki R, Muranaka T, Ninh KB, Fujiyama K, Seki H (2018). Transcriptome sequencing and identification of cytochrome P450 monooxygenases involved in the biosynthesis of maslinic acid and corosolic acid in Avicennia marina. Plant Biotechnol 35: 341-348. DOI: 10.5511/plantbiotechnology.18.0810a
Takagi K, Yano R, Tochigi S, Fujisawa Y, Tsuchinaga H, Takahashi Y, Takada Y, Kaga A, Anai T, Tsukamoto C, Seki H, Muranaka T, Ishimoto M (2018). Genetic and functional characterization of Sg-4 glycosyltransferase involved in the formation of sugar chain structure at the C-3 position of soybean saponins. Phytochemistry 156: 96-105. DOI: 10.1016/j.phytochem.2018.09.002
Suzuki H, Fukushima E.O, Umemoto N, Ohyama K, Seki H, Muranaka T (2018). Comparative analysis of CYP716A subfamily enzymes for the heterologous production of C-28 oxidized triterpenoids in transgenic yeast. Plant Biotechnol 35: 131-139. DOI: 10.5511/plantbiotechnology.18.0416a
Muangphrom P, Seki H, Matsumoto S, Nishiwaki M, Fukushima EO, Muranaka T (2018). Identification and characterization of a novel sesquiterpene synthase, 4-amorphen-11-ol synthase, from Artemisia maritima. Plant Biotechnol 35: 113-121. DOI: 10.5511/plantbiotechnology.18.0324a
Tamura K, Yoshida K, Hiraoka Y, Sakaguchi, D, Chikugo A, Mochida K, Kojoma M, Mitsuda N, Saito K, Muranaka T, Seki H (2018). The basic helix-loop-helix transcription factor GubHLH3 positively regulates soyasaponin biosynthetic genes in Glycyrrhiza uralensis. Plant Cell Physiol 59(4): 783-796. DOI: 10.1093/pcp/pcy046
Yano R, Takagi K, Tochigi S, Fujisawa Y, Nomura Y, Tsuchinaga H, Takahashi Y, Takada Y, Kaga A, Anai T, Tsukamoto C, Seki H, Muranaka T, Ishimoto M (2018). Isolation and characterization of the soybean Sg-3 gene that is involved in genetic variation in sugar chain composition at the C-3 position in soyasaponins. Plant Cell Physiol 59(4): 797-810. DOI: 10.1093/pcp/pcy019
解説・総説、著書
Seki H, Tamura K, Muranaka T (2018). Plant-derived isoprenoid sweeteners: recent progress in biosynthetic gene discovery and perspectives on microbial production. Biosci Biotech Biochem 82(6): 927-934. DOI: 10.1080/09168451.2017.1387514
鈴木秀幸、關 光、刑部祐里子、刑部敬史、村中俊哉 (2018). 18章 オーム科学と植物バイオテクノロジー、基礎から学ぶ植物代謝生化学、羊土社（東京）228-243.
2017
原著論文
Tamura K, Teranishi Y, Ueda S, Suzuki H, Kawano N, Yoshimatsu K, Saito K, Kawahara N, Muranaka T, Seki H (2017). Cytochrome P450 monooxygenase CYP716A141 is a unique β-amyrin C-16β oxidase involved in triterpenoid saponin biosynthesis in Platycodon grandiflorus. Plant Cell Physiol 58(5): 874-884. DOI: 10.1093/pcp/pcx043
Kobayashi K, Kobayashi K, Yamaguchi H, Miyagi-Inoue Y, Takagi K, Fushihara K, Seki H, Suzuki M, Nagata N, Muranaka T (2017). Platform for “Chemical Metabolic Switching” to increase sesquiterpene content in plants. Plant Biotechnol 34(1): 65-69. DOI: 10.5511/plantbiotechnology.17.0114a
Yasumoto S, Seki H, Shimizu Y, Fukushima EO, Muranaka T (2017). Functional characterization of CYP716 family P450 enzymes in triterpenoid biosynthesis in tomato. Front Plant Sci 8:21. DOI: 10.3389/fpls.2017.00021
Tamura K, Seki H, Suzuki H, Kojoma M, Saito K, Muranaka T (2017). CYP716A179 functions as a triterpene C-28 oxidase in tissue-cultured stolons of Glycyrrhiza uralensis. Plant Cell Rep 36(3): 437-445. DOI: 10.1007/s00299-016-2092-x
Mochida K*, Sakurai T*, Seki H, Yoshida T, Takahagi K, Sawai S, Uchiyama H, Muranaka T, Saito K (*equal contribution) (2017). Draft genome assembly and annotation of Glycyrrhiza uralensis, a medicinal legume. Plant J 89(2): 181-194. DOI: 10.1111/tpj.13385
新聞掲載（2016-10-25、化学工業日報）
解説・総説、著書
Muangphrom P, Seki H, Muranaka T (2017). Revealing the catalytic residues of amorpha-4,11-diene synthase (ADS): new insight for engineering terpene synthases. Biotarget 1:19. DOI: 10.21037/biotarget.2017.12.03
關 光 (2017). 第7章 農業と食料生産（翻訳）、ビジュアルバイオテクノロジー、化学同人（京都）
2016
原著論文
Umemoto N, Nakayasu M, Ohyama K, Yotsu-Yamashita M, Mizutani M, Seki H, Saito K, Muranaka T (2016). Two cytochrome P450 monooxygenases catalyze early hydroxylation steps in the potato steroid glycoalkaloid biosynthetic pathway. Plant Physiol 171(4): 2458-2467. DOI: 10.1104/pp.16.00137
新聞掲載（2016-08-08、日本経済新聞、他）
Muangphrom P, Seki H, Suzuki M, Komori A, Nishiwaki M, Mikawa R, Fukushima EO, Muranaka T (2016). Functional analysis of amorpha-4,11-diene synthase (ADS) homologs from non-artemisinin-producing artemisia species: The discovery of novel koidzumiol and (+)-α-bisabolol synthases. Plant Cell Physiol 57(8): 1678-1688. DOI: 10.1093/pcp/pcw094 (Selected as the Editor’s choice article)
Tsukagoshi Y, Ohyama K, Seki H, Akashi T, Muranaka T, Suzuki H, Fujimoto Y (2016). Functional characterization of CYP71D443, a cytochrome P450 catalyzing C-22 hydroxylation in the 20-hydroxyecdysone biosynthesis of Ajuga hairy roots. Phytochemistry 127: 23-28. DOI: 10.1016/j.phytochem.2016.03.010
Tsukagoshi Y, Suzuki H, Seki H, Muranaka T, Ohyama K, Fujimoto Y (2016). Ajuga Δ24-sterol reductase catalyzes the direct reductive conversion of 24-methylenecholesterol to campesterol. J Biol Chem 291(15): 8189-8198. DOI: 10.1074/jbc.M115.703470
Yasumoto S, Fukushima EO, Seki H, Muranaka T (2016). Novel triterpene oxidizing activity of Arabidopsis thaliana CYP716A subfamily enzymes. FEBS Lett 590(4): 533-540. DOI: 10.1002/1873-3468.12074
解説・総説、著書
關 光、田村啓太、村中俊哉 (2016). 植物の非糖質系天然甘味成分の生合成、FFIジャーナルVol. 221(3): 225-231.
Muangphrom P, Seki H, Fukushima EO, Muranaka T (2016). Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites. J Nat Med 70(3): 318-334. DOI: 10.1007/s11418-016-1008-y
2015
解説・総説、著書
關 光 (2015). 薬用植物研究の最前線、生物工学会誌 Vol. 93(7): 413.
Seki H*, Tamura K, Muranaka T (*corresponding author) (2015). P450s and UGTs: key players in the structural diversity of triterpenoid saponins. Plant Cell Physiol 56(8): 1463-1471. DOI: 10.1093/pcp/pcv062
安本周平、關 光、刑部祐里子、刑部敬史、村中俊哉 (2015). 第11章 植物でのゲノム編集、実験医学別冊 論文だけではわからない ゲノム編集成功の秘訣Q&A、羊土社（東京）228-243.
安本周平、關 光、村中俊哉 (2015). 第３章 第２節 人工ヌクレアーゼを用いた植物代謝工学、進化するゲノム編集技術、エヌ・ティー・エス（東京）235-241.
2014
原著論文
Muangphrom P, Suzuki M, Seki H, Fukushima EO, Muranaka T (2014). Functional analysis of orthologous artemisinic aldehyde Δ11(13)-reductase reveals potential artemisinin-producing activity in non-artemisinin-producing Artemisia absinthium. Plant Biotechnol 31(5): 483-491. DOI: 10.5511/plantbiotechnology.14.0807a
Okazawa A, Kusunose T, Ono E, Kim HJ, Satake H, Shimizu, B, Mizutani M, Seki H, Muranaka T (2014). Glucosyltransferase activity of Arabidopsis UGT71C1 towards pinoresinol and lariciresinol. Plant Biotechnol 31(5): 561-566. DOI: 10.5511/plantbiotechnology.14.0910a
Sawai S*, Ohyama K*, Yasumoto S, Seki H, Sakuma T, Yamamoto T, Takebayashi Y, Kojima M, Sakakibara H, Aoki T, Muranaka T, Saito, K, Umemoto N (*equal contribution) (2014). Sterol side chain reductase 2, a key enzyme for biosynthesis of cholesterol as the common precursor of toxic steroidal glycoalkaloids in potato. Plant Cell 26(9): 3763-3774.
DOI: 10.1105/tpc.114.130096
メディア報道（2014-09-14、日経バイオテクONLINE、他）
解説・総説、著書
安本周平、關 光、村中俊哉 (2014). TALENを用いたゲノム編集による植物代謝改変、生物工学会誌 Vol. 92(10): 553-555.
安本周平、關 光、村中俊哉 (2014). 植物（シロイヌナズナ）におけるTALENを用いた遺伝子改変、今すぐ始めるゲノム編集、実験医学別冊、羊土社（東京）189-199.
關 光、田村啓太、村中俊哉 (2014). 第２章 トリテルペノイド生合成におけるP450 の多様な機能—薬用植物・生薬の最前線、シーエムシー出版（東京）132-139.
Fukushima EO, Seki H, Muranaka T (2014). Heterologous expression of triterpene biosynthetic genes in yeast and subsequent metabolite identification through GC-MS. Methods Mol Biol 1153: 235-243. DOI: 10.1007/978-1-4939-0606-2_17
Fukushima EO, Seki H, Muranaka T (2014). Plant cytochrome P450s in triterpenoid biosynthesis: Diversity and application to combinatorial biosynthesis. In: Fifty years of cytochrome P450 research. Hiroshi Yamazaki (Ed.). Springer Japan. pp. 125-133. DOI: 10.1007/978-4-431-54992-5_7
2013
原著論文
Fukushima EO, Seki H, Sawai S, Suzuki M, Ohyama K, Saito K, Muranaka, T (2013). Combinatorial biosynthesis of legume natural and rare triterpenoids in engineered yeast. Plant Cell Physiol 54(5): 740-749. DOI: 10.1093/pcp/pct015
Ramilowski J, Sawai S, Seki H, Mochida K, Yoshida T, Sakurai T, Muranaka T, Saito K, Daub C (2013). Glycyrrhiza uralensis transcriptome landscape and study of phytochemicals. Plant Cell Physiol 54(5): 697-710. DOI: 10.1093/pcp/pct057
Komori A, Suzuki M, Seki H, Nishizawa T, Meyer JJ, Shimizu H, Yokoyama S, Muranaka T (2013). Comparative functional analysis of CYP71AV1 natural variants reveals an important residue for the successive oxidation of amorpha-4,11-diene. FEBS Lett 587(3): 278-284 (2013). DOI: 10.1016/j.febslet.2012.11.031
解説・総説、著書
福島エリオデット、關 光、村中俊哉 (2013). 植物テルペノイド代謝の多様性とコンビナトリアル生合成、生物工学会誌 Vol. 91(6): 337-341.
Suzuki H, Takita E, Ohyama K, Sawai S, Seki H, Sakurai N, Muranaka T, Ishimoto M, Sudo H, Saito K, Shibata D (2013). Multi-gene transformation for pathway engineering of secondary metabolites. The Handbook of Plant Metabolomics. 227-244. DOI: 10.1002/9783527669882.ch12
大山 清、關 光、村中俊哉 (2013). 第9章 カンゾウの有用トリテルペノイド配糖体—グリチルリチン生合成とその応用、機能性配糖体の合成と応用、シーエムシー出版（東京）81-89.
2012
原著論文
Kunii M, Kitahama Y, Fukushima EO, Seki H, Muranaka T, Yoshida Y, Aoyama Y (2012). β-Amyrin oxidation by oat CYP51H10 expressed heterologously in yeast cells: The first example of CYP51-dependent metabolism other than the 14-demethylation of sterol precursors. Biol Pharm Bull 35(5): 801-804. DOI: 10.1248/bpb.35.801
解説・総説、著書
關 光、村中俊哉 (2012). 組換え酵母を用いた植物由来有用トリテルペノイドの生産、バイオサイエンスとインダストリー、Vol. 70(3): 192-195.
2011
原著論文
Fukushima EO*, Seki H*, Ohyama K, Ono E, Umemoto N, Mizutani M, Saito K, Muranaka T (*equal contribution) (2011). CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis. Plant Cell Physiol 52(12): 2050-2061. DOI: 10.1093/pcp/pcr146
新聞掲載（2011-12-19、朝日新聞、産経新聞、他）
Seki H*, Sawai S*, Ohyama K*, Mizutani M, Ohnishi T, Sudo H, Fukushima EO, Akashi T, Aoki T, Saito K, Muranaka T (*equal contribution) (2011). Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin. Plant Cell 23(11): 4112-4123.
DOI: 10.1105/tpc.110.082685
新聞掲載（2011-11-26、朝日新聞、読売新聞、他）
解説・総説、著書
關 光、村中俊哉 (2011). 組換え酵母を用いた植物トリテルペノイドの生産、生物工学会誌 Vol. 89(11): 656-659.
澤井 学、關 光、大山 清、村中俊哉、斉藤和季 (2011). グリチルリチンなどトリテルペノイドの遺伝子組換え酵母での生産、BIO INDUSTRY Vol. 28 (12): 6-12.
2010
原著論文
Kojoma M, Ohyama K, Seki H, Hiraoka Y, Asazu S-N, Sawa S, Sekizaki H, Yoshida S, Muranaka T (2010). In vitro proliferation and triterpenoid characteristics of licorice (Glycyrrhiza uralensis Fischer, Leguminosae) stolons. Plant Biotechnol 27(1): 59-66. DOI: 10.5511/plantbiotechnology.27.59
解説・総説、著書
Mano K, Nemoto K, Suzuki M, Seki H, Fujii I, Muranaka T (2010). The AMI1 gene family: indole-3-acetamide hydrolase functions in auxin biosynthesis in plants. J Exp Bot 61(1): 25-32. DOI: 10.1093/jxb/erp292
2009
原著論文
Nemoto K, Hara M, Suzuki M, Seki H, Oka A, Muranaka T, Mano Y (2009). Function of the aux and rol genes of the Ri plasmid in plant cell division in vitro. Plant Signal Behav 4(12): 38-41. DOI: 10.4161/psb.4.12.9904
Nemoto K, Hara M, Goto S, Kasai K, Seki H, Suzuki M, Oka A, Muranaka T, Mano Y (2009). The aux1 gene of the Ri plasmid is sufficient to confer auxin autotrophy in tobacco BY-2 cells. J Plant Physiol 166(7): 729-738. DOI: 10.1016/j.jplph.2008.09.006
Sudo H, Seki H, Sakurai N, Suzuki H, Shibata D, Toyoda A, Totoki Y, Sakaki Y, Iida O, Shibata T, Kojoma M, Muranaka T, Saito K (2009). Expressed sequence tags from rhizomes of Glycyrrhiza uralensis. Plant Biotechnol 26(1): 105-107. DOI: 10.5511/plantbiotechnology.26.105
Nemoto K, Hara M, Suzuki M, Seki H, Muranaka T, Mano Y (2009). The NtAMI1 gene functions in cell division of tobacco BY-2 cells in the presence of indole-3-acetamide. FEBS Lett 583(2): 487-492. DOI: 10.1016/j.febslet.2008.12.049
解説・総説、著書
村中俊哉、關 光、大山 清 (2009). カンゾウのグリチルリチン生合成遺伝子ディスカバリーと今後の研究展開、ファルマシアVol. 45(9): 865-869.
關 光、大山 清、村中俊哉 (2009). 薬用植物甘草のグリチルリチン生合成遺伝子の発見 -組み換え酵母で生合成中間体の生産に成功-、化学と生物Vol. 47(2): 84-86.
2008
原著論文
Seki H, Ohyama K, Sawai S, Mizutani M, Ohnishi T, Sudo H, Akashi T, Aoki T, Saito K, Muranaka T (2008). Licorice β-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin. Proc Natl Acad Sci USA 105(37): 14204-14209.
DOI: 10.1073/pnas.0803876105
新聞掲載（2008-09-09、朝日新聞、産経新聞、他）
Seki H, Ohyama K, Nishizawa T, Yoshida Y, Muranaka T (2008). The “all-in-one” rol-type binary vectors as a tool for functional genomic studies using hairy roots. Plant Biotechnol 25(4): 347-355. DOI: 10.5511/plantbiotechnology.25.347
Asakura Y, Seki H, Muranaka T, Yamamura Y, Kurosaki F (2008). Enhanced secretory activity of Atropa belladonna hairy root culture over-expressing ADP-ribosylation factor gene. Biol Pharm Bull 31(7): 1465-1468. DOI: 10.1248/bpb.31.1465
2007
原著論文
Kobayashi K, Suzuki M, Tang J, Nagata N, Ohyama K, Seki H, Kiuchi R, Kaneko Y, Nakazawa M, Matsui M, Matsumoto S, Yoshida S, Muranaka T (2007). LOVASTATIN INSENSITIVE 1, a novel pentatricopeptide repeat protein, is a potential regulatory factor of isoprenoid biosynthesis in Arabidopsis. Plant Cell Physiol 48(2): 322-331. DOI: /10.1093/pcp/pcm005
Shen Q-H, Saijo Y, Mauch S, Biskup C, Bieri S, Keller B, Seki H, Ülker B, Somssich IE, Schulze-Lefert P (2007). Nuclear activity of MLA immune receptors links isolate-specific and basal disease resistance responses. Science 315(5815): 1098-1103. DOI: 10.1126/science.1136372
2006
原著論文
Kojoma M, Seki H, Yoshida S, Muranaka T (2006). DNA polymorphisms in the tetrahydrocannabinolic acid (THCA) synthase gene in "drug-type" and "fiber-type" Cannabis sativa L. Forensic Sci Int 159(2-3): 132-140. DOI: 10.1016/j.forsciint.2005.07.005
Suzuki M*, Xiang T*, Ohyama K, Seki H, Saito K, Muranaka T, Hayashi H, Katsube Y, Kushiro T, Shibuya M, Ebizuka Y (*equal contribution) (2006). Lanosterol synthase in dicotyledonous plants. Plant Cell Physiol 47(5): 565-571. DOI: 10.1093/pcp/pcj031
解説・総説、著書
關 光、村中俊哉 (2006). 毛状根培養系の新展開 〜毛状根培養による物質生産研究20年目にあたって〜、バイオサイエンスとインダストリーVol. 64(5): 17-22.
高上馬希重、關 光、吉田茂男、村中俊哉 (2006). Cannabis sativa L.のドラッグタイプとファイバータイプにおけるTHCA生合成酵素遺伝子の多型検出、DNA多型Vol. 14：123-129.
2005
原著論文
Seki H, Nishizawa T, Tanaka N, Niwa Y, Yoshida S, Muranaka T (2005). Hairy root-activation tagging: a high-throughput system for activation tagging in transformed hairy roots. Plant Mol Biol 59(5): 793-807. DOI: 10.1007/s11103-005-1008-x
2004
原著論文
Suzuki M*, Kamide Y*, Nagata N*, Seki H, Ohyama K, Kato H, Masuda K, Sato S, Kato T, Tabata S, Yoshida S, Muranaka T (*equal contribution) (2004). Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduces sterol level. Plant J 37(5): 750-761. DOI: 10.1111/j.1365-313X.2004.02003.x
2002
原著論文
Seki H, Nakamura N, Marutani M, Okabe T, Sanematsu S, Inagaki Y, Toyoda K, Shiraishi T, Yamada T, Ichinose Y (2002). Molecular cloning of cDNA for a novel pea Dof protein, PsDof1, and its DNA binding activity to the promoter of PsDof1 gene. Plant Biotechnol 19(4): 251-260. DOI: 10.5511/plantbiotechnology.19.251
2001
原著論文
Imura Y, Seki H, Toyoda K, Ichinose Y, Shiraishi T, Yamada T (2001). Contrary operations of Box-I element of pea phenylalanine ammonia-lyase gene 1 promoter for organ-specific expression. Plant Physiol Biochem 39(5): 355-362. DOI: 10.1016/S0981-9428(01)01248-7
Ichinose Y, Hisayasu Y, Sanematsu S, Ishiga Y, Seki H, Toyoda K, Shiraishi T, Yamada T (2001). Molecular cloning and functional analysis of cDNA E86 encoding homologous protein to hypersensitivity related hsr203J. Plant Sci 160(5): 997-1006. DOI: 10.1016/S0168-9452(01)00343-0
解説・総説、著書
Yamada T, Ichinose Y, Shiraishi T, Toyoda K, Imura Y, Seki H, Sriprasertsak P, Funado A (2001). Regulation of nuclear gene expression in relation to signal molecules. In Delivery and perception of pathogen signals in plants. Eds. Keen, N. et al., pp. 164-173, APS Press, St. Paul, Minnesota, USA. ISBN 978-0-89054-259-0
1999
原著論文
Kato H, Sriprasertsak P, Seki H, Ichinose Y, Shiraishi T, Yamada T (1999). Functional analysis of retrotransposons in pea. Plant Cell Physiol 40(9): 933-941. DOI: 10.1093/oxfordjournals.pcp.a029625
Seki H, Nagasugi Y, Ichinose Y, Shiraishi T, Yamada T (1999). Changes in in vivo DNA-protein interactions in pea phenylalanine ammonia-lyase and chalcone synthase gene promoter induced by fungal signal molecules. Plant Cell Physiol 40(1): 88-95. DOI: 10.1093/oxfordjournals.pcp.a029478
解説・総説、著書
Shiraishi T, Yamada T, Ichinose Y, Kiba A, Toyoda K, Kato T, Murakami Y, Seki, H (1999). Suppressor as a factor determining plant-pathogen specificity. In Plant-Microbe Interaction. Eds. Stacey, G. and Keen, N. pp. 121-161, APS Press, St. Paul, Minnesota, USA. ISBN 978-0-89054-228-6
1998
解説・総説、著書
山田哲治、田中良和、関 光、井村喜之、Permpong Sriprasertsak、Andi Salamah、一瀬勇規、白石友紀、豊田和弘 (1998). 植物の抵抗性と防御応答に関する遺伝子発現，植物と病原体の情報応答機構（真山滋志・土佐幸雄編）日本植物病理学会（東京）125-133.
1997
原著論文
Seki H, Ichinose Y, Ito M, Shiraishi T, Yamada T (1997). Combined effects of multiple cis-acting elements in elicitor-mediated activation of PSCHS1 gene. Plant Cell Physiol 38(1): 96-100. DOI: 10.1093/oxfordjournals.pcp.a029092
1996
原著論文
Seki H, Ichinose Y, Kato H, Shiraishi T, Yamada T (1996). Analysis of cis-regulatory elements involved in the activation of a member of chalcone synthase gene family (PsChs1) in pea. Plant Mol Biol 31(3): 479-491. DOI: 10.1007/BF00042222
解説・総説、著書
Yamada T, Shiraishi T, Ichinose Y, Kato H, Seki H, Murakami Y (1996). Regulation of the genes involved in phenylpropanoid pathway in pea by elicitor and suppressor. In Molecular Aspects of Pathogenicity and Resistance: Requirement for Signal Transduction. Eds. Mills, D. et al., pp. 151-162, APS Press, St. Paul, Minnesota, USA. ISBN 978-0-89054-215-6