コース業績

2010 | 2011 | 2012 | 2013 | 2014 | 2015| 2016| 2017

受賞（コース全体）

  1. 2016年3月 Sastia Prama Putri（助教）　ロレアル-ユネスコ女性科学賞
  2. 2016年3月 竹尾映美（学部4年）大阪大学工学賞
  3. 2016年6月 角倉早紀（博士前期課程1年）　第64回日本質量分析総合討論会ベストプレゼンテーション賞
  4. 2016年9月 安本周平（博士後期課程3年）　平成28年度日本植物細胞分子生物学会学生奨励賞
  5. 2016年9月 松浦友亮（准教授）　平成28年度生物工学奨励賞（斎藤賞）
  6. 2016年9月 熊谷仁志（博士後期課程3年）　第68回日本生物工学会大会若手口頭発表優秀賞
  7. 2016年10月 角倉早紀（博士前期課程1年）　International BMS Symposium Award
  8. 2016年10月 Adinda Putri Wisman（博士前期課程2年） International BMS Symposium Award
  9. 2016年10月 Phan Nguyen Thuy An（博士前期課程3年） International BMS Symposium Award
  10. 2016年12月 鈴木 和志(博士後期課程3年) The 20th ISIR International Symposium Poster Award for young scientist
  11. 2016年12月 加藤泰彦（助教）　第39回日本分子生物学会年会優秀ポスター賞

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生物資源工学領域（福崎研）

Original Papers
  1. Shimma S, Kumada HO, Taniguchi H, Konno A, Yao I, Furuta K, Matsuda T, Ito S.
    (2016) Microscopic visualization of testosterone in mouse testis by use of imaging mass spectrometry.
    Anal. Bioanal. Chem. 408, 7607-7615.
  2. Moriyama, T., Tanaka, S., Nakayama, Y., Fukumoto, M., Tsujimura, K., Yamada, K., Bamba, T., Yoneda, Y. and Fukusaki, E., Oka, M.
    (2016) Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network.
    Sci Rep. 6, 34648.
  3. Kuboniwa, M., Sakanaka, A., Hashino, E., Bamba, T., Fukusaki, E. and Amano, A.
    (2016) Prediction of Periodontal Inflammation via Metabolic Profiling of Saliva.
    J Dent Res. 95, 1381-1386.
  4. Mitsunaga, H., Meissner, L., Büchs, J. and Fukusaki, E.
    (2016) Branched chain amino acids maintain the molecular weight of poly(γ-glutamic acid) of Bacillus licheniformis ATCC 9945 during the fermentation.
    J Biosci Bioeng. 122, 400-5.
  5. Chun, S., Bamba, T., Suyama, T., Ishijima, T., Fukusak,i E., Abe, K. and Nakai, Y.
    (2016) A High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis.
    PLoS One. 11.
  6. Sano, T., Iwahashi, M., Imagi, J., Sato, T., Yamashita, T., Fukusaki, E. and Bamba T.
    (2016) Relationship between 3-Methyl-2,4-nonanedione Concentration and Intensity of Light-induced Off-odor in Soy Bean Oil.
    J Oleo Sci. 65, 447-50.
  7. Nakano, Y., Yamashita, T., Okuno, M., Fukusaki, E. and Bamba, T.
    (2016) In vitro steroid profiling system for the evaluation of endocrine disruptors.
    J Biosci Bioeng. 2016 122, 370-7.
  8. Teoh, S. T., Kitamura, M., Nakayama, Y., Putri, S., Mukai, Y. and Fukusaki, E.
    (2016) Random Sample Consensus combined with Partial Least Squares regression (RANSAC-PLS) for microbial metabolomics data mining and phenotype improvement.
    J Biosci Bioeng. 122, 168-75.
  9. Hori, K., Hori-Koriyama, N., Tsumura, K., Fukusaki, E. and Bamba, T.
    (2016) Insights into the formation mechanism of chloropropanol fatty acid esters under laboratory-scale deodorization conditions.
    J Biosci Bioeng. 122, 246-51.
  10. Mitsunaga, H., Meissner, L., Palmen, T., Bamba, T., Büchs, J. and Fukusaki, E.
    (2016) Metabolome analysis reveals the effect of carbon catabolite control on the poly(γ-glutamic acid) biosynthesis of Bacillus licheniformis ATCC 9945.
    J Biosci Bioeng. 121, 413-9.
  11. Jumhawan, U., Putri. S. P., Yusianto, Bamba, T. and Fukusaki, E.
    (2016) Quantification of coffee blends for authentication of Asian palm civet coffee (Kopi Luwak) via metabolomics: A proof of concept.
    J Biosci Bioeng. 122, 79-84.
  12. Ohta, E., Nakayama, Y., Mukai, Y., Bamba, T. and Fukusaki, E.
    (2016) Metabolomic approach for improving ethanol stress tolerance in Saccharomyces cerevisiae.
    J Biosci Bioeng. 121, 399-405
  13. Konya, Y., Bamba, T. and Fukusaki E.
    (2016) Extra-facile chiral separation of amino acid enantiomers by LC-TOFMS analysis.
    J Biosci Bioeng. 121, 349-53.
  14. Noguchi, S., Putri, S. P., Lan, E. I., Laviña, W. A., Dempo, Y., Bamba, T., Liao, J. C. and Fukusaki, E.
    (2016). Quantitative target analysis and kinetic profiling of acyl-CoAs reveal the rate-limiting step in cyanobacterial 1-butanol production.
    Metabolomics. 12, 26.
Reviews
  1. 新間秀一，竹尾映美，福崎英一郎
    （2016）イメージング質量分析における定量分析
    分析化学，第65巻，12号，745-750.
  2. 新間秀一，角倉早紀，安田優太郎，竹尾映美，福崎英一郎
    （2016）見たいものを「みる」ためのイメージング質量分析ー現状と今後の課題ー.
    表面科学，第37巻，12号，593-598.
  3. 福崎英一郎
    （2016）バイオ系のキャリアデザイン「流れにまかせて三十年」
    生物工学会誌，第94巻，第12号，779-783.　
  4. 傳寳雄大，福崎英一郎
    （2016）メタボロミクス技術開発と高解像度表現型解析への応用
    日本薬学会構造活性相関部会・ニュースレター, 1-8.
  5. 福崎英一郎
    (2016) メタボロミクス技術の食品機能解析への応用
    G.I. Research 2016年8月号 (Vol. 24, No.4), 253-259.
  6. 福崎英一郎
    (2016) メタボミクスの技術開発と精密表現型解析への応用（平成27年度生物工学功績賞受賞論文）
    生物工学会誌，vol.94, no.5, 230-236
  7. 中谷航太，和泉自泰，福崎英一郎，馬場健史
    (2016)メタボローム解析の現状と新規分析技術の開発
    G.I. Research, vol.24, no.4, 228-233.
  8. 三村奈津紀，磯谷敦子，岩下和裕，福崎英一郎
    (2016) メタボロミクス技術を用いた清酒の成分プロファイリングと品質評価.
    バイオサイエンスとインダストリー，vol.74, No. 4, 293-297.

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ゲノム機能工学領域

Original Papers
  1. Kaboli, S., Miyamoto, T., Sunada, K., Sasano, Y., Sugiyama, M. and Harashima, S.
    (2016) Improved stress resistance and ethanol production by segmental haploidization of the diploid genome in Saccharomyces cerevisiae.
    J. Biosci. Bioeng. 121, 638-644.
  2. Sugiyama, M., Akase, SP., Nakanishi, R., Kaneko, Y. and Harashima, S.
    (2016) Overexpression of ESBP6 improves lactic acid resistance and production in Saccharomyces cerevisiae.
    J. Biosci. Bioeng. 122, 415-420.
  3. Sasano, Y., Nagasawa, K., Kaboli, S., Sugiyama, M. and Harashima, S.
    (2016) CRISPR-PCS: a powerful new approach to inducing multiple chromosome splitting in Saccharomyces cerevisiae.
    Sci. Rep. 17, 30278.
  4. Kitichantaropas, Y., Boonchird C., Sugiyama, M., Kaneko, Y., Harashima, S., Auesukaree, C.
    (2016) Cellular mechanisms contributing to multiple stress tolerance in Saccharomyces cerevisiae strains with potential use in high-temperature ethanol fermentation.
    AMB Express. 6, 107.
Reviews
  1. 杉山峰崇，笹野 佑，鈴木 俊宏，原島 俊
    (2016) 高温・有機酸ストレス耐性出芽酵母の育種と発酵生産への利用．
    化学と生物 54, 820-826

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生命環境システム工学領域（渡邉研）

Original Papers
  1. Uyeda, A., Nakayama, S., Kato, Y., Watanabe, H. and Matsuura, T.
    (2016) Construction of an in Vitro Gene Screening System of the E. coli EmrE Transporter Using Liposome Display.
    Anal. Chem. 88, 12028-12035.
  2. Ohta, N., Kato, Y., Watanabe, H., Mori, H. and Matsuura, T.
    (2016) In vitro membrane protein synthesis inside Sec translocon-reconstituted cell-sized liposomes.
    Sci. Rep. 6, 36466.
  3. Nakanishi, T., Kato, Y., Matsuura, T. and Watanabe, H.
    (2016) TALEN-mediated knock-in via non-homologous end joining in the crustacean Daphnia magna.
    Sci. Rep. 6, 36252.
  4. Mohamad Ishak, N. S., Kato, Y., Matsuura, T. and Watanabe, H.
    (2016) Sequence Conservation and Sexually Dimorphic Expression of the Ftz-F1 Gene in the Crustacean Daphnia magna.
    PLoS One. 11, e0154636.

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細胞動態学領域

Original Papers
  1. Sugiyama, M., Yagi, H.,Ishii, K., Porcar, L., Martel, A, Oyama, K., Noda, M., Yunoki, Y., Murakami, R., Inoue, R., Sato, N., Oba, Y., Terauchi, K., Uchiyama, S., and Kato, K.
    (2016) Structural characterization of the circadian clock protein complex composed of KaiB and KaiC by inverse contrast-matching small-angle neutron scattering.
    Sci. Rep. 6, 35567.
  2. Zhang, Z., Ohto, U., Shibata, T., Krayukhina, E., Taoka, M., Yamauchi, Y., Tanji, H., Isobe, T., Uchiyama, S., Miyake, K., and Shimizu, T.
    (2016) Structural analysis reveals that Toll-like receptor 7 is a dual receptor for guanosine and single-stranded RNA. Immunity 45, 737-748.
  3. Satoh, T., Toshimori, T., Noda, M., Uchiyama, S., and Kato, K.
    (2016) Crystal structure of ER glucosidase II heterodimeric complex consisting of catalytic subunit and its binding domain of regulatory subunit.
    Protein Sci. 25, 2095-2101.
  4. Inoue, R., Takata, T., Fujii, F., Ishii, K., Uchiyama, S., Sato, N., Oba, Y., Wood, K., Kato, K., Fujii, N., Sugiyama, M.
    (2016) New insight into the dynamical system of αB-crystallin oligomers.
    Sci. Rep. 6, 29208.
  5. Ishii, K., Noda, M., Uchiyama S.
    (2016) Mass spectrometric analysis of protein–ligand interactions.
    Biophysics and Physicobiology 13, 87-95.
  6. Ohto, U., Ishida, H., Krayukhina, E., Uchiyama, S., Inoue, N.,, Shimizu, S.
    (2016) Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization.
    Nature 534, 566-569.
  7. Oda, M., Tanabe, Y., Noda, M., Inaba, S., Krayukhina, E., Fukada, H., Uchiyama, S.
    (2016) Structural and binding properties of laminarin revealed by analytical ultracentrifugation and calorimetric analyses.
    Carbohydrate Research 431, 33-36.
  8. Nango, E., Akiyama, S., Maki-Yonekura, S., Ashikawa, Y., Kusakabe, Y., Krayukhina, E., Maruno, T., Uchiyama, S., Nuemket, N., Yonekura, K., Shimizu, M., Atsumi, N., Yasui, N., Hikima, T., Yamamoto, M., Kobayashi, Y., and Yamashita, A.
    (2016) Taste substance binding elicits conformational change of taste receptor T1r heterodimer extracellular domains.
    Sci. Rep. 6, 25745.
  9. Kabe, Y., Nakane, T., Koike, I., Yamamoto, T., Sugiura, Y., Harada, E., Sugase, K., Shimamura, T., Ohmura, M., Muraoka, K., Yamamoto, A., Uchida, T., Iwata, S., Yamaguchi, Y., Krayukhina, E., Noda, M., Handa, H., Ishimori, K., Uchiyama, S., Kobayashi T., and Suematsu, M.
    (2016) Haem-dependent dimerization of PGRMC1/sigma-2 receptor facilitates cancer proliferation and chemoresistance.
    Nature Comm. 7, 11030.
  10. Fukai-Toma, S. Kim, J.D., Park, K. E., Kuwabara, N., Shimizu, N., Krayukuhina, E., Uchiyama, S., Fukamizu, A., Shimizu, T.
    (2016) Novel helical assembly in arginine methyltransferase 8.
    J. Mol. Biol. 428, 1197-1208.
  11. Fujikawa, A., Nagahira, A., Sugawara, H., Ishii, K., Imajo, S., Matsumoto, M., Kuboyama, K., Suzuki, R., Tanga, N., Noda, M., Uchiyama, S., Tomoo, T., Ogata, A., Masumura, M., and Noda, M.
    (2016) Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma.
    Sci. Rep. 6, 20473.
  12. Thammaporna, R., Ishii, K., Yagi-Utsumi, M., Uchiyama, S., Hannongbua, S., and Kato, K.,
    (2016) Mass spectrometric characterization of HIV-1 reverse transcriptase interactions with non-nucleoside reverse transcriptase inhibitors.
    Biological and Pharmaceutical Bulletin 39, 450-454.
  13. Amano, M., Fukui, K., Uchiyama, S.
    (2016) Suppression of methionine oxidation of a pharmaceutical antibody stored in a polymer-based syringe.
    J. Pharm. Sci. 105, 623-629.
Reviews
  1. Uchiyama, S., Arisaka, F.
    (2016) Important and essential theoretical aspects of AUC.
    Analytical Ultracentrifugation, Instrumentation, Software, and Applications, Uchiyama, S., Arisaka, F., Stafford, W.F., Laue, T. (Eds.), Springer, P3-14.
  2. Arisaka, F., Uchiyama, S.
    (2016) Experimental design and practical aspect.
    Analytical Ultracentrifugation, Instrumentation, Software, and Applications, Uchiyama, S., Arisaka, F., Stafford, W.F., Laue, T. (Eds.), Springer, P15-21.
  3. Saito, S., Uchiyama, S.
    (2016) Biopharmaceuticals - Evaluation of intermolecular interactions by AUC-SE-.
    Analytical Ultracentrifugation, Instrumentation, Software, and Applications, Uchiyama, S., Arisaka, F., Stafford, W.F., Laue, T. (Eds.), Springer, P419-440.
  4. Uchiyama S.
    (2016) Biophysical Characterization of Biopharmaceuticals, Including Antibody Drugs.
    Yakugaku Zasshi. 136, 443-8.
  5. Uchiyama S. and Fukui K.
    (2016) Condensin in chromatid cohesion and segregation.
    Cytogenet. Genome Res. 147, 212-216.

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細胞工学領域（村中研）

Original Papers
  1. Yasumoto, S., Fukushima, E.O., Seki, H. and Muranaka, T.
    (2016) Novel triterpene oxidizing activity of Arabidopsis thaliana CYP716A subfamily enzymes.
    FEBS Lett. 590, 533-540.
  2. Tsukagoshi, Y., Suzuki, H., Seki, H., Muranaka, T., Ohyama, K. and Fujimoto, Y.
    (2016) Ajuga Δ24-sterol reductase catalyzes the direct reductive conversion of 24-methylenecholesterol to campesterol.
    J. Biol. Chem. 291, 8189-8198.
  3. Tsukagoshi, Y., Ohyama, K., Seki, H., Akashi, T., Muranaka, T., Suzuki, H. and Fujimoto, Y.
    (2016) Functional characterization of CYP71D443, a cytochrome P450 catalyzing C-22 hydroxylation in the 20-hydroxyecdysone biosynthesis of Ajuga hairy roots.
    Phytochemistry 127, 23-28.
  4. Muangphrom, P., Seki, H., Suzuki, M., Komori, A., Nishiwaki, M., Mikawa, R., Fukushima, E.O. and Muranaka, T.
    (2016) Functional analysis of amorpha-4,11-diene synthase (ADS) homologs from non-artemisinin-producing artemisia species: The discovery of novel koidzumiol and (+)-α-bisabolol synthases.
    Plant Cell Physiol. 57, 1678-1688.
  5. Umemoto, N., Nakayasu, M., Ohyama, K., Yotsu-Yamashita, M., Mizutani, M., Seki, H., Saito, K. and Muranaka. T.
    (2016) Two cytochrome P450 monooxygenases catalyze early hydroxylation steps in the potato steroid glycoalkaloid biosynthetic pathway.
    Plant Physiol. 171, 2458-2467.
Reviews
  1. Muangphrom, P., Seki, H., Fukushima, E.O. and Muranaka. T.
    (2016) Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites.
    J. Nat. Med. 70, 318-334.
  2. 關 光, 田村啓太, 村中俊哉
    (2016) 植物の非糖質系天然甘味成分の生合成
    FFIジャーナル 221, 225-231.
  3. 安本周平, 村中俊哉
    (2016) 植物でのゲノム編集の利用 ゲノム編集入門 －ZFN・TALEN・CRISPR-Cas9－
    裳華房 (東京) 160–183.
  4. 安本周平, 村中俊哉
    (2016) 農作物でのゲノム編集All Aboutゲノム編集“革命的技術”はいかにして私たちの研究・医療・産業を変えるのか？
    羊土社 (東京) 158-163.

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合成生物工学領域

Original Papers
  1. Cheng, M., Yoshiyasu, H., Okano. K., Ohtake, H., and Honda, K.
    (2016) Redirection of the reaction specificity of a thermophilic acetolactate synthase toward acetaldehyde formation.
    PLoS One 11, e0146146.
  2. Honda, K., Hara, N., Cheng, M., Nakamura, A., Mandai, K., Okano, K., and Ohtake, H.
    (2016) In vitro metabolic engineering for the salvage synthesis of NAD. Metab. Eng. 35, 114-120.
  3. Okano, K., Yamamoto, Y., Takano, H., Aketo, T., Honda, K.,and Ohtake, H.
    (2016) A simple technology for phosphorus recovery using acid-treated concrete sludge. Separ. Purif. Technol. 165, 173-178.
  4. Polburee, P., Yongmanitchai, W., Honda, K., Ohashi, T., Yoshida, T., Fujiyama, K. (()) Lipid production from biodiesel-derived crude glycerol by Rhodosporidium fluviale DMKU-RK253 using temperature shift with high cell density. Biochem. Eng. J. 112, 208-218.
  5. Okano, K., Miyamaru, S., Yamamoto, Y., Kunisada, M., Takano, H., Toda, M., Honda, K., and Ohtake, H.
    (2016) A mobile pilot-scale plant for in situ demonstration of phosphorus recovery from wastewater using amorphous calcium silicate hydrates. Separ. Purif. Technol. 170, 116-121.
Reviews
  1. Honda, K.
    (2016) Chapter 16, Industrial applications of multistep enzyme reactions.
    G. Brahmachari, A. Demain, J.L. Adrio edn.
    Biotechnology of Microbial Enzymes, Elsevier, 433-450.
  2. 加藤純一, 田島誉久, 黒田章夫, 廣田隆一, 本田孝祐, 大竹久夫
    (2016) 低炭素ケミカル生産のためのシンプル酵素触媒
    ケミカルエンジニヤリング 61, 165-169.
  3. 岡野憲司, 本田孝祐
    (2016) 耐熱性酵素を用いたニコチンアミド補酵素の安定化技術の開発
    ケミカルエンジニヤリング 61, 44-50

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生物プロセスシステム工学領域（紀ノ岡研）

Original Papers
  1. Sonoi, R., Kim, M.-H. and Kino-oka, M.
    (2016) Facilitation of uniform maturation of human retinal pigment epithelial cells through collective movement in culture.
    J. Biosci. Bioeng. 121, 220-226.
  2. Kagawa, Y. and Kino-oka, M.
    (2016) An in silico prediction tool for the expansion culture of human skeletal muscle myoblasts.
    R. Soc. Open Sci. 3：160500.
  3. Ogawa, Y., Kim, M.-H. and Kino-oka, M.
    (2016) Migration-driven aggregate behaviors of human mesenchymal stem cells on a dendrimer-immobilized surface direct differentiation toward a cardiomyogenic fate commitment.
    J. Biosci. Bioeng. 122, 627-632.
  4. Mizutani, M., Samejima, H., Terunuma, H. and Kino-oka, M.
    (2016) Experience of contamination during autologous cell manufacturing in cell processing facility under the Japanese Medical Practitioners Act and the Medical Care Act.
    Regenerative Therapy 5, 25-30.

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生物工学国際交流センター（仁平研）

Original Papers
  1. Sultan, S. P., Kitani, S., Miyamoto, K.T., Iguchi, H., Atago, T., Ikeda, H., and Nihira, T.
    (2016) Characterization of AvaR1, a butenolide-autoregulator receptor for biosynthesis of a Streptomyces hormone in Streptomyces avermitilis.
    Appl. Microbiol. Biotechnol. 100, 9581-9591.
  2. Intra, B., Euanorasetr, J., Nihira, T., and Panbangred, W.
    (2016) Characterization of a γ-butyrolactone synthetase gene homologue (stcA) involved in bafilomycin production and aerial mycelium formation in Streptomyces sp. SBI034.
    Appl. Microbiol. Biotechnol. 100, 2749-2760.
  3. Kurniawan, Y.N., Kitani, S., Iida, A., Maeda, A., Nijeholt, J.L., Lee, Y.J., and Nihira, T.
    (2016) Regulation of production of the blue pigment indigoidine by the pseudo γ-butyrolactone receptor FarR2 in Streptomyces lavendulae FRI-5.
    J. Biosci. Bioeng. 121, 372-379.
  4. Kinoshita, H., Yoshioka, M., Ihara, F., and Nihira, T.
    (2016) Cryptic antifungal compounds active by synergism with polyene antibiotics.
    J. Biosci. Bioeng. 121, 394-398.
Reviews
  1. 木谷茂、仁平卓也
    (2016) 放線菌ホルモンによる二次代謝制御メカニズムと有用物質生産への応用
    JSM Mycotoxins. 66, 73-79.
  2. 木谷茂、仁平卓也
    (2016) 放線菌に潜在する有用物質生産能力に魅せられて
    生物工学会誌 94, 387-389.
  3. 木谷茂
    (2016) 微生物の可能性は有限？無限？
    バイオサイエンスとインダストリー 74, 341.

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生物工学国際交流センター（藤山研）

Original Papers
  1. Ohashi, T., Hasegawa, Y., Misaki, R. and Fujiyama, K.
    (2016) Substrate preference of citrus naringenin rhamnosyltransferases and their application to flavonoid glycoside production in fission yeast.
    Appl. Micobiol. Biotechnol. 100, 687-96.
  2. Roongsawang, N., Puseenam, A., Kitikhun, S., Sae-Tang, K., Harnpicharnchai, P., Ohashi, T., Fujiyama, K., Tirasophon, W. and Tanapongpipat, S.
    (2016) A novel potential signal peptide sequence and overexpression of ER-resident chaperones enhance heterologous protein secretion in thermotolerant methylotrophic yeast Ogataea thermomethanolica.
    Appl. Biochem. Biotechnol. 178, 710-24.
  3. Trempel, F., Kajiura, H., Ranf, S., Grimmer, J., Westphal, L., Zipfel, C., Scheel, D., Fujiyama, K. and Lee, J.
    (2016) Altered glycosylation of exported proteins, including surface immune receptors, compromises calcium and downstream signaling responses to microbe-associated molecular patterns in Arabidopsis thaliana.
    BMC Plant Biol. 16:31.
  4. Limkul, J., Iizuka, S., Sato, Y., Misaki, R., Ohashi, T., Ohashi, T. and Fujiyama, K.
    (2016) The production of human glucocerebrosidase in glyco-engineered Nicotiana benthamiana plants.
    Plant Biotechnol. J. 14, 1682-94.
  5. Polburee, P., Yongmanitchai, W., Honda, K., Ohashi, T., Yoshida, T., Fujiyama, K. and Limtong, S.
    (2016) Lipid production from biodiesel-derived crude glycerol by Rhodosporidium fluviale DMKU-RK253 using temperature shift with high cell density.
    Biochem. Eng. J. 112, 208-18.
  6. Takamatsu, S., Shimomura, M., Kamada, Y., Maeda, H., Sobajima, T., Hikita, H., Iijima, M., Okamoto, Y., Misaki, R., Fujiyama, K., Nagamori, S., Kanai, Y., Takehara, T., Ueda, K., Kuroda, S. and Miyoshi E.
    (2016) Core-fucosylation plays a pivotal role in hepatitis B pseudo virus infection: a possible implication for HBV glycotherapy.
    Glycobiology. 26, 1180-1189.
  7. Misaki, R., Fukura, N., Kajiura, H., Yasugi, M., Kubota-Koketsu, R., Sasaki, T., Momota, M., Ono, K., Ohashi, T., Ikuta, K. and Fujiyama, K.
    (2016) Recombinant production and characterization of human anti-influenza virus monoclonal antibodies identified from hybridomas fused with human lymphocytes.
    Biologicals.44, 394-402.
  8. De Martinis, D., Rybicki, E.P., Fujiyama, K., Franconi, R. and Benvenuto, E.
    (2016) Editorial: Plant Molecular Farming: Fast, Scalable, Cheap, Sustainable.
    Front Plant Sci. 7, 1148.

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産業科学研究所生体分子機能科学講座（永井研）

Original Papers
  1. Morikawa, TJ., Fujita, H., Kitamura, A., Horio, T., Yamamoto, J., Kinjo, M., Sasaki, A., Machiyama, H., Yoshizawa, K., Ichimura, T., Imada, K., Nagai, T and Watanabe, TM.
    (2016) Dependence of fluorescent protein brightness on protein concentration in solution and enhancement of it.
    Sci Rep. 6, 22342.
  2. Pandey, K., Ferreira, PE., Ishikawa, T., Nagai, T., Kaneko, O. and Yahata, K.
    (2016) Ca2+ monitoring in Plasmodium falciparum using the yellow cameleon-Nano biosensor.
    Sci Rep. 6, 23454.
  3. Lissek, T., Obenhaus, HA., Ditzel, DA., Nagai, T., Miyawaki, A., Sprengel, R. and Hasan, MT.
    (2016) General Anesthetic Conditions Induce Network Synchrony and Disrupt Sensory Processing in the Cortex.
    Front. Cell. Neurosci. 10, 64(1-14).
  4. Ohta, Y., Kamagata, T., Mukai, A., Takada, S., Nagai, T. and Horikawa, K.
    (2016) Nontrivial Effect of the Color-Exchange of a Donor/Acceptor Pair in the Engineering of Förster Resonance Energy Transfer (FRET)-Based Indicators.
    ACS Chem Biol. 11, 1816-1822.
  5. Sakamaki, K., Ishii, TM., Sakata, T., Takemoto, K., Takagi, C., Takeuchi, A., Morishita, R., Takahashi, H., Nozawa, A., Shinoda, H., Chiba, K., Sugimoto, H., Saito, A., Tamate, S., Satou, Y., Jung, SK., Matsuoka, S., Koyamada, K., Sawasaki, T., Nagai, T. and Ueno N.
    (2016) Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage.
    Biochim Biophys Acta. 1863, 2766-2783.
  6. Lu-Walther, HW., Hou, W., Kielhorn, M., Arai, Y., Nagai, T., Kessels, MM., Qualmann, B. and Heintzmann, R.
    (2016) Nonlinear Structured Illumination Using a Fluorescent Protein Activating at the Readout Wavelength.
    PLoS One. 11, e0165148(1-14).
  7. Shimada, N., Saito, M., Shukuri, S., Kuroyanagi, S., Kuboki, T., Kidoaki, S., Nagai, T. and Maruyama A.
    (2016) Reversible Monolayer/Spheroid Cell Culture Switching by UCST-Type Thermoresponsive Ureido Polymers.
    ACS Appl Mater Interfaces. 8, 31524-31529.
  8. Mochida, S., Rata, S., Hino, H., Nagai, T. and Novák, B.
    (2016) Two Bistable Switches Govern M Phase Entry. Curr Biol. 26, 3361-3367.
  9. Takemoto, K., Iwanari, H., Tada, H., Suyama, K., Sano, A., Nagai, T., Hamakubo, T. and Takahashi, T.
    (2016) Optical inactivation of synaptic AMPA receptors erases fear memory.
    Nat Biotechnol. 35, 38-47.
  10. Suzuki, K., Kimura, T., Shinoda, H., Bai, G., Daniels, MJ., Arai, Y., Nakano, M. and Nagai T.
    (2016) Five colour variants of bright luminescent protein for real-time multicolour bioimaging.
    Nat Commun. 14, 13718(1-10).
Reviews
  1. 稲垣成矩、永井健治
    (2016) 遺伝子にコードされた膜電位センサーによる神経活動計測の現状と展望
    Drug Delivery System, 31, 119-126
  2. Inagaki, S and Nagai, T.
    (2016) Current progress in genetically encoded voltage indicators for neural activity recording.
    Curr Opin Chem Biol. 33, 9-5.
  3. 松田知己
    (2016) 蛍光タンパク質―知っておきたい性質―
    生物工学会誌 94, 555-558.

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物質生命工学コース生物化学工学領域（大政研）

Original Papers
  1. Badsha, M.B., Kurata, H., Onitsuka, M., Oga, T. and Omasa, T.
    (2016) Metabolic analysis of antibody producing CHO cell culture under different stresses conditions.
    Journal of Bioscience and Bioengineering, 122, 1, 117-124.
  2. Yamano, N., Takahashi, M., Ali Haghparast, S.M., Onitsuka, M., Kumamoto, T., Frank, J. and Omasa, T.
    (2016) Increased recombinant protein production owing to expanded opportunities for vector integration in high chromosome number Chinese hamster ovary cells.
    Journal of Bioscience and Bioengineering, 122, 2, 226-231.
  3. Okochi, M., Kamiya, T., Omasa, T., Tanaka, T. and Honda, H.
    (2016) Rapid colorimetric antibody detection using a dual-function peptide probe for silver nanoparticle aggregation and antibody recognition.
    Analytical Sciences, 32, 1 , 93-97.
  4. Uehara, R., Takano, K., Kanaya, S. and Koga, Y.
    (2016) Hyperthermophilic subtilisin-like protease from Themococcus kodakarensis. Biotechnology of Microbial Enzymes, production, biocatalysis and industrial applications,
    Academic Press, p81-117.
  5. Matsuyama, R., Yamano, N., Kawamura, N. and Omasa, T.
    (2016) Lengthening of high-yield production levels of monoclonal antibody-producing Chinese hamster ovary cells by downregulation of breast cancer 1.
    Journal of Bioscience and Bioengineering, 123, 3, 382-389.
Reviews
  1. Nakashima, Y. and Omasa, T.
    (2016) What kind of signaling maintains pluripotency and viability in human-induced pluripotent stem cells cultured on laminin-511 with serum-free medium?
    Bioreseach Open Access., 5, 1, 84–93.
  2. 大政健史
    (2016)バイオ医薬品生産における小胞体ストレス応答の応用
    薬学雑誌, 136 (6), 831-839.
  3. 大政健史
    (2016) 産業生物化学工学-動物細胞の産業応用を目指した次世代バイオ医薬品生産
    大阪大学工業会誌テクノネット, 573, 3-7.

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情報科学研究科バイオ情報工学専攻代謝情報工学講座（清水研）

Original Papers
  1. Matsushima, Y., Hirasawa, T. and Shimizu, H.
    (2016) Enhancement of 1,5-diaminopentane production in a recombinant strain of Corynebacterium glutamicum by Tween 40 addition.
    J. Gen. Appl. Microbiol. 62(1),42-45.
  2. Hayakawa, K., Matsuda, F. and Shimizu, H.
    (2016) Metabolome analysis of Saccharomyces cerevisiae and optimization of culture medium for S-adenosyl-L-methionine production.
    AMB Express 6(1),1-8.
  3. Maeda, K., Okahashi, N., Toya, Y., Matsuda, F. and Shimizu, H.
    (2016) Investigation of useful carbon tracers for 13C-metabolic flux analysis of Escherichia coli by considering five experimentally determined flux distributions.
    Metab.Eng.Comm. 3,187-195.
  4. Matsuda, F.
    (2016) Regular expressions of MS/MS spectra for partial annotation of metabolite features.
    Metabolomics 12,113
  5. Okahashi, N., Kawana, S., Iida, J., Shimizu, H. and Matsuda, F.
    (2016) GC-MS/MS survey of collision-induced dissociation of tert-butyldimethylsilyl-derivatized amino acids and its application to 13C -metabolic flux analysis of Escherichia coli central metabolism.
    Anal. Bioanal. Chem. 408(22), 6133-6140
  6. Nugroho, R,H., Yoshikawa, K., Matsuda, F. and Shimizu, H.
    (2016) Positive effects of proline addition on the central metabolism of wild-type and lactic acid-producing Saccharomyces cerevisiae strains.
    Biopro cess Biosyst. Eng. 39(11),1711-1716.
  7. Wada, K., Toya, Y., Banno, S., Yoshikawa, K., Matsuda, F. and Shimizu, H.
    (2016) 13C-metabolic flux analysis for mevalonate producing Escherichia coli.
    J. Biosci. Bioeng. 123(2),177-182.
  8. Namakoshi, K., Nakajima, T., Yoshikawa, K., Toya, Y. and Shimizu, H.
    (2016) Combinatorial deletions of glgC and phaCE enhance ethanol production in Synechocystis sp. PCC 6803.
    J. Biotechnol. 239,13-19.
  9. Nakajima, T., Yoshikawa, K., Toya, Y., Matsuda, F. and Shimizu, H.
    (2016) Metabolic flux analysis of Synechocystis sp. PCC6803 ΔnrtABCD mutant reveals a mechanism for metabolic adaptation to nitrogen-limited conditions.
    Plant Cell Physiol. 58(3), 537-545.
Reviews
  1. Matsuda, F.
    (2016) Technical challenges in mass spectrometry-based metabolomics.
    Mass Spectrometry, 5.
  2. Hirasawa, T. and Shimizu, H.
    (2016) Recent advances in amino acid production by microbial cells.
    Curr. Opin. Biotechnol. 42, 133-146.

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情報科学研究科バイオ情報工学専攻共生ネットワークデザイン学講座

Original Papers
  1. Bansho, Y., Furubayashi, T., Ichihashi, N.* and Yomo, T.* (*co-corresponding)
    (2016) Host-parasite oscillation dynamics and evolution in a compartmentalized RNA replication system.
    Proc. Nat. Aca. Sci. USA, 113, 4045-4050.
  2. Mizuuchi, R., Ichihashi, N.* and Yomo, T. (*corresponding)
    (2016) Adaptation and diversification of an RNA replication system under initiation- or termination-impaired translational conditions.
    ChemBioChem, 17, 1229-1232.
  3. Sunami, T., Ichihashi, N., Nishikawa, T., Kazuta, Y. and Yomo, T.
    (2016) Effect of Liposome Size on Internal RNA Replication Coupled with Replicase Translation.
    ChemBioChem, 17, 1282-1289.
  4. Aita, T., Ichihashi, N. and Yomo, T.
    (2016) Inference of fitness values and putative appearance time points for evolvable self-replicating molecules from time series of occurrence frequencies in an evolution reactor.
    J. Theoretical Biol., 401, 38-42.
Reviews
  1. Ichihashi, N. and Yomo, T.
    (2016) Constructive approaches for understanding the origin of self-replication and evolution.
    Life, 6, 26-37.

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